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Idiopathic recurring stupor(IRS)is a disease of unknown pathogenesis presenting with recurrent stuporous states.We describe three IRS patients in whom there were no metabolic,toxic,or structural brain dysfunctions. Ictal EEGs were characterized by fast(14-to 16-Hz),unreactive background activity.Flumazenile,a benzodiazepine receptor antagonist,promptly resolved the clinical and EEG picture.In all patients,ictal plasma determination showed a marked increase in benzodiazepine-like activity identified as endozepine-4.IRS may be due to an unexplained excess of endozepine-4. |
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